I had a full hysterectomy, my omentum lining taken out and my appendix and 20 lymph nodes were taken out and. The 5year overall survival is below 45% and it decreases to 25% among patients with advanced oc. Normal and calcified cardiac valve groups, as well as positive nanobacteria strain se90 and negative serum radiated with 30 kgy of. Recent data proposing an extremely small, selfreplicating agent termed nanobacteria has raised a great deal of controversy within the scientific community.
Detection of nanobacterialike material from calcified. Human infection with nanobacteria may be the result of consuming meat from infected cows and getting contaminated bovine serum vaccines. This article is based on material in the book the calcium bomb. Hudelist g, singer cf, kubista e, manavi m, mueller r, et al.
The female reproductive system contains two ovaries, one on each side of the uterus. The debate would have ended there, except for a steadily increasing number of studies linking nanobacteria to serious health problems, including kidney stones, aneurysms and ovarian cancer. Ocrf is the leading independent agency dedicated to advancing ovarian cancer research in the united states. Nadzeya goncharenkokhaider, denis lane, isabelle matte, claudine rancourt and alain piche february 27th 20. There are several factors that contribute to the high deathtoincidence. Nov 10, 2014 growing medical data suggest that nanobacteria, small bacteria that cover themselves with calcium, are the cause of most atherosclerosis, commonly known as hardening of the arteries. Read nanobacteria promote crystallization of psammoma bodies in ovarian cancer, apmis on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Research on nanobacteria has gained momentum in recent years with an increasing number of reports showing their occurrence in human diseases. Nanobacteria were implicated in gallbladder and renal stone formations, polycystic kidney diseases, rheumatoid arthritis, coinfections with hiv, ovarian and nasopharyngeal cancer, alzheimers disease, and chronic.
Nano drug delivery systems for ovarian cancer therapy. Presently nanobacteria are considered to be a crystaline formation rather than a bacteria. Evidence for pathogenetic role in intratumoral biomineralization. Presence of cnp in ovarian cancer calcifications proven by another austrian group, 16s rrna sequence supporting the first bacterial classification kajander and ciftcioglu 1998 was repeated hudelist et al. There is also data indicating that approximately 93 percent of kidney stones are due to. Apr, 2020 an unfortunate statistic of ovarian cancer is that one out of 57 women who visit the clinic have ovarian tumors and approximately 60% of them are already in advanced stage national cancer. The existing evidence that nanobacteria nb are closely associated with human disease is overwhelming. It results in abnormal cells that have the ability to invade or spread to other parts of the body. Department of obstetrics and gynaecology, division of special gynaecology, university of vienna medical centre, vienna. The ovarian cancer research fund is a 501c 3 notforprofit organization founded in 1994 with a mission to fund research to find a method of early detection and ultimately a cure for ovarian cancer. Structural biochemistryovarian cancer wikibooks, open. Cytotoxicity and apoptosis induced by nanobacteria in human breast cancer cells mingjun zhang,1 shengnan liu,1 ge xu,2 yanan guo,1 jiannan fu,3 dechun zhang11molecular medicine and tumor research center, chongqing medical university, 2electron microscopy group, department of life science, chongqing medical university, chongqing, peoples. Nanobacteria are the smallest cellwalled organisms on earth, the existence of which is the center of great controversy. Presence of nanobacteria in psammoma bodies of ovarian cancer.
Kajander himself recently admitted that the bacterial status of nb is still lacking satisfactory evidence, and he concedes that the term calcifying nanoparticle best describes the agent 38. Kajander1,2 1 department of biochemistry, university of kuopio, kuopio, finland 2 nanobac pharmaceuticals, inc. Nanobacteria promote crystallization of psammoma bodies in. Dec 01, 2004 read presence of nanobacteria in psammoma bodies of ovarian cancer. Men with prostate disease often have it, as do kidneystone sufferers. Purported nanobacteria in human blood as calcium carbonate. Nanobacteria cannot be killed by penicillin, cephalosporins, marolides and most other antibiotics, heat under 196 f, freezing, dehydration and gamma radiation under 150 mrad demir, 2008. Ovarian cancer early detection, diagnosis, and staging. When this process begins, there may be no or only vague symptoms. Epithelial ovarian cancer, ovarian cancer stem cells, cancer stem cells markers, tumor microenvironment, therapeutic targets.
Nanobacteria were implicated in gallbladder and renal stone formations, polycystic kidney diseases, rheumatoid arthritis, coinfections with hiv, ovarian and nasopharyngeal cancer, alzheimers disease, and chronic prostatitis. Nanometer scale objects hypothesized to be a type of bacteria nanobacteria are associated with calcified geological specimens, human kidney stones, and psammona bodies in ovarian cancer. Since contemporary biology is strongly based on molecular biochemical outlook on life and there is an apparently insurmountable abyss between. Apr 08, 2008 research on nanobacteria has gained momentum in recent years with an increasing number of reports showing their occurrence in human diseases. Regular womens health exams during a pelvic exam, the health care professional feels the ovaries and uterus for size, shape, and consistency. Nov 29, 2004 furthermore, nanobacterial mrna was detectable in all of the four tissues 100% that contained psammoma bodies, but was absent in all 10 ovarian cystadenocarcinomas 0% that were psammoma negative. Purported nanobacteria in human blood as calcium carbonate nanoparticles jan martel and john dinge young department of biochemistry and cellular molecular biology, chang gung university, 259 wenhua first road, kweishan, taoyuan 333, taiwan. Part of each valve was immunostained with nanobacterial antibody 8d10, and the remaining parts were homogenized, filtered, and maintained in culture. Secondly, it was observed that the crystalline structures were shown to grow and replicate.
Jan 10, 2006 recent data proposing an extremely small, selfreplicating agent termed nanobacteria has raised a great deal of controversy within the scientific community. The ovaries each about the size of an almond produce eggs ova as well as the hormones estrogen and progesterone. Cytotoxicity and apoptosis induced by nanobacteria in. Because theres no standard screening test and the symptomswhich. The objective of this study was to investigate the cytotoxic effects. Daily ovarian cancer updates from hundreds of medical resources. Ovarian cancer biomarkers for molecular biosensors and. Germ cells usually form the ova or eggs in females and the sperm in males. Oct 01, 2003 read nanobacteria promote crystallization of psammoma bodies in ovarian cancer, apmis on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Soon after, discoveries of nb were extended to biological tissues and fluids results that further attested to the ubiquitous nature of nb and to their potential role in health and disease. A case study on what it means to be a biological organism by merri lynn casem department of biological science california state university, fullerton part iwhat does it mean to be alive.
Ovarian cancer digests, journals, abstracts, breaking news, clinical trials, research, genetics,new drugs, trials, chemotherapy, in the news drugs on the. Positively charged gold nanoparticles are usually toxic to cells, but cancer cells somehow. Experiments were designed to evaluate human vascular tissue for the presence of similar nanometerscale objects. Ovarian cancer is a type of cancer that begins in the ovaries. Under the microscope nanobacteria propagating calcifying. Several lines of evidence suggest the involvement of these organisms in the process of biomineralization. Introduction ovarian cancer is the fifth most common type of cancer in females and the leading cause of mortality for gynecological malignancies, with epithelial carcinoma being the most frequent variety. Epithelial ovarian carcinoma oc is the most lethal gynaecological neoplasm.
Growing medical data suggest that nanobacteria, small bacteria that cover themselves with calcium, are the cause of most atherosclerosis, commonly known as hardening of the arteries. Biological significance of apoptosis in ovarian cancer. Whether a single cell or a sequoia tree, a humpback whale or a. Although ovarian cancer has a lifetime risk of only 1. Ovarian cancer trial is assessing cantrixil as a therapy. When ovarian cancer is found early, about 94% of patients live longer than 5 years after diagnosis. May 25, 2007 hudelist g, singer cf, kubista e, manavi m, mueller r, et al. Pdf an overview on clinical implications of nanobacteria. Such heterogeneity is the result of sharp differences in the biology that underlies the development and the natural history of the oc variants. Read presence of nanobacteria in psammoma bodies of ovarian cancer. Symptoms become more noticeable as the cancer progresses. Detection of nanobacteria infection in type iii prostatitis. Introduction ovarian cancer is the fifth most common type of cancer in females and the leading cause of mortality.
Nanobacteria are thought to play an important role in extraskeletal calcifying diseases including stones formation, urolithiasis and polycystic kidney disease kajander et al. Thomas hjelleb nanobacteria are unconventional agents 100fold smaller than common bacteria that can replicate apatiteforming units. Apr 18, 2020 soon after, discoveries of nb were extended to biological tissues and fluids results that further attested to the ubiquitous nature of nb and to their potential role in health and disease. We found a 100% concordance between the expression of nanobacteria and the presence of psammoma bodies in malignant ovarian tumours.
The role of nanobacteria in urologic disease springerlink. The etiology of type iii prostatitis remains unclear to date, although the recently discovered nanobacteria nb have been implicated in this disease. Cytotoxicity and apoptosis induced by nanobacteria in human breast cancer cells mingjun zhang,1 shengnan liu,1 ge xu,2 yanan guo,1 jiannan fu,3 dechun zhang11molecular medicine and tumor research center, chongqing medical university, 2electron microscopy group, department of life science, chongqing medical university, chongqing, peoples republic of china. Discovery of new ovarian cancer signaling hub points to. A key objective of the phase 1 trial nct02903771, which began enrolling participants in august 2016, is to see if cantrixil is safe for patients with recurring ovarian cancer. Is there anyone out there who is stage 1a where the cancer cell was encapsulated in the cyst but it was clear cell. While more people are outliving cancer overall death rates have fallen 22 percent since 1991, ovarian cancer remains stubbornly hard to beat. Under the microscope nanobacteria propagating calcifying nanoparticles e. An april 2008 pnas article also reported that blood nanobacteria are not living organisms and stated that caco3 precipitates prepared in vitro are remarkably similar to purported nanobacteria in terms of their uniformly sized, membranedelineated vesicular shapes, with cellular divisionlike. Nano drug delivery systems for ovarian cancer therapy canan hascicek and ozge gun ankara university, faculty of pharmacy, department of pharmaceutical technology, turkey abstract ovarian cancer is the second most common gynecologic cancer in europe and the usa, and the most fatal gynecologic malignancy among all cancers with a mortality rate. Psammoma bodies in two types of human ovarian tumours. Nanobacteria are phylogenetically close relatives of mineral forming bacteria kajander et al. Ovarian cancer begins in the ovary, one of a pair of female reproductive organs located in the pelvis on either side of the uterus.
If you have ever had a vaccine, you may harbour nanobacteria in your blood, tissues, and organs. View enhanced pdf access article on wiley online library html view. The treatment for fallopian tube cancer is much like that for ovarian cancer, but the outlook prognosis is slightly better. There are basically two ways to determine if nanobacteria are present in your body. Most ovarian germ cell tumors are benign, but some are cancerous and may be life threatening. Purported nanobacteria in human blood as calcium carbonate nanoparticles. These hard tissues are biocomposites and incorporate both structural macromolecules lipids, proteins, and polysaccharides and inorganic minerals. Nanobacterium sanguineum is the first calcium phosphate mineral containing nanoorganism isolated from human blood that causes pathological disease calcification in humans.
Ovarian cancer is a type of cancer which abnormal cells begin to grow in one or both of a womans ovaries. The trial partners in the united states are the peggy and charles stephenson cancer center and the mary crowley cancer research center. How gold nanoparticles can help fight ovarian cancer. Review investigating molecular profiles of ovarian cancer. We found a 100% concordance between the expression of nanobacteria and the. Positively charged gold nanoparticles are usually toxic to. Presence of nanobacteria in psammoma bodies of ovarian. Discovery of new ovarian cancer signaling hub points to target for limiting metastasis. Approximately 240,000 new cases of oc are diagnosed every year, with 140,000 patients succumbing to the disease. Nanobacteria do not exist and simply represent nanoparticles. Since these agents have been isolated within the genitourinary tract, much research has focused attention on the potential role these particles may play in the development of urologic pathology, including polycystic kidney disease. Ovarian cancer kills over 125,000 women worldwide each year and kills more women than all other gynecologic cancers combined. Cytotoxicity and apoptosis induced by nanobacteria in human.
A nanobacterium is by definition one billionth of a meter in diameter 110 the size of bacteria, leaving some to question whether or not an organism of this size has enough room to house necessary cell components such as dna, rna, and plasmids. For the 60 million americans who have heart disease, most have calcification. Nanobacteria are powerful mediators of biogenic apatite. The genus nanobacterium is said to contain a group of microbes that, like the name suggests, have dimensions considerably lower than that of regular bacteria, and perhaps even rival those of viruses. Diagnosis and management of ovarian cancer american.
To investigate the relationship between nanobacterial infection and type iii prostatitis. Furthermore, nanobacterial mrna was detectable in all of the four tissues 100% that contained psammoma bodies, but was absent in all 10 ovarian cystadenocarcinomas 0% that were psammoma negative. An unfortunate statistic of ovarian cancer is that one out of 57 women who visit the clinic have ovarian tumors and approximately 60% of them are already in advanced stage national cancer. However, their potential toxicity against cancer cells has not yet been reported. Most cases of ovarian cancer occur in women older than age 55. Of the millions of women who develop breast or ovarian cancer or who have breast implants, calcification is a warning. Since its discovery, nanobacteria have been the subject of consistent controversy. Including humans, many multicellular organisms produce similar hard tissues, such as bones, teeth, shells, skeletal units, and spicules.